Who was it that said "paranoia is reality on a finer scale" or something like that?
Our corporate standard is McAfee and is used on their mail servers. At my division, I use CA InnoculateIT on my Notes server. All other servers/clients use NAV CE. Count 'em, that's three teirs of protection. Some get through the first (McAfee), some the second (CA), but I've yet to be let down by the third (NAV.
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Give a man a fish and he will be back for more. Slap him with a fish and he will go away forever.