I got it setup to check if there is a profile and if nothing is found set the registry key to open a default PRF file. It also creates and sets the signatures in the same script and they are still there when outlook is started for the first time.
Have a look at the post below. This is how I did it at my previous job and I'm also implementing it at my current job.

http://www.kixtart.org/forums/ubbthreads.php?ubb=showflat&Number=200649
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Mart

- Chuck Norris once sold ebay to ebay on ebay.