This has been in testing here and looks reasonably well compared to any other products out there for an Enterprise.

Spy Sweeper Enterprise - v2.0
http://www.webroot.com/

http://www.webroot.com/products/spysweeper/enterprise/?WRSID=0fc7c08d72af977672df604f0fed213c

Quote:

What is Webroot Spy Sweeper Enterprise?

Webroot Spy Sweeper Enterprise is a centrally-managed, comprehensive spyware and adware solution for corporations. Using a client / server architecture, Spy Sweeper Enterprise proactively detects and removes all forms of spyware, adware and other unwanted programs within the organization. Spy Sweeper Enterprise effectively manages the corporate spyware threat by reducing security risks, minimizing support requests and reestablishing computing and network performance.

Webroot Spy Sweeper Enterprise provides

Centralized management via the admin console
Manual or automated deployment of definition updates and product upgrades
Advanced desktop-level protection with Active Shields to prevent new infections
Customizable protection and security policies
Definition updates and sweep schedule retention for laptop and mobile users while away from network
Fully customizable reporting
Most comprehensive detection and elimination of spyware, adware and other unwanted programs available