Also, welcome to the board.

By kixtart it is possible to create a new DOS box (= vdm) to run an
application. Memory management will be good in such situation.
We have never modify for Windows 9x/NT/W2K memory management part.
We are using always the default configuration for it.

How to create a new DOS box by running kixtart?

SHELL '%comspec% /c your_application.exe'

by using SHELL 'your_application.exe' you are running in current
environment space. same space were kix32.exe is running.

Greetings.