The pro's for InstallShield mentioned by Chris are the same Wise uses to indicate why we should use Wise. However, our experience with Wise Package Studio are positive:
- Fast reply from Wise when having problems
- Wise Knowledge base
- as from 4.5:
* central package repository
* ability to check new (or bought) packages
against this repository

There is one negative point i know about InstallShield packages and that is that if you use KiXforms & use Shell to install the package, the installation freezes (see the bug forum at the KiXforms site).

Nevertheless, i think MSI's can be created by both packages without much effort, so the price makes the difference..
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Kind regards,